Short for “proliferation” therapy, prolotherapy, similar to PRP is used to help strengthen tendons and ligaments. However, prolotherapy is more commonly done with ligaments (as PRP is now more commonly done with tendons). Prolotherapy involves injecting typically a hypertonic glucose solution to actually irritate and reinitiate the body’s own inflammatory and healing process. The healing process is especially important at the attachment sites of the ligaments on the bone referred to as the “-enthesis.” This helps to strengthen the tendon or ligament, thus prolotherapy is commonly used when laxity or loose hypermobile, subluxing, or dislocating joints are a concern.

Common indications for prolotherapy: